Genomic, Ancestry & Admixture Dashboard • GRCh37 VCF Analysis
PJL (Punjabi sampled in Lahore) alongside West Coast South Asian groups (Karnataka, Cochin, Konkan).
| Ancestral Stream | Share | Historical Period, Archeology & Evolutionary Context |
|---|---|---|
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Indus Periphery / Sarazm-EN Ancient Iranian Farmers |
Represents the ancient agriculturalists from the Iranian Plateau and Tajikistan (Sarazm Early Neolithic) who migrated into the Indus River valley around 4000–3000 BCE.
🏺 Historical Context: Formed the demographic foundation of the urban Indus Valley Civilisation (Mohenjo-daro & Harappa).
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AASI (Onge Proxy) Indigenous South Asian |
Ancestral Ancient South Indian (AASI). Derived from the first Out-of-Africa human migrations who inhabited the Indian subcontinent for over 40,000 years.
🏹 Historical Context: Represents the indigenous hunter-gatherer genetic baseline of South Asia.
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Steppe MLBA (Sintashta) Bronze Age Herders |
Bronze Age Pastoralist herders from the Sintashta & Andronovo cultures (~2000–1500 BCE) who migrated into South Asia.
🐎 Historical Context: Introduced Indo-Aryan languages into the subcontinent and carried the paternal Y-chromosome lineage R1a-Z93.
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Adjust the 3 ancient components to see how changing the ratio of Indus Valley, AASI, and Steppe MLBA dynamically updates the chart and calculates model fit distance against the empirical qpAdm baseline.
| Rank | Population Reference | Distance | Detailed Regional Context & Significance |
|---|---|---|---|
| #1 | Cochin_Jew_B | 0.1309 |
Local South Indian / Kerala baseline coordinates without recent Middle Eastern admixture.
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| #2 | Karnataka_Muslim | 0.1378 |
West Coast Indian population from Karnataka reflecting shared coastal genetic affinity.
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| #3 | Mumbai_Jew | 0.1395 |
Bene Israel reference group representing Western Indian (Maharashtra/Konkan) genetic baseline.
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| #4 | Knanaya | 0.1396 |
Endogamous Christian group from Kerala with high genetic stability.
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| #5 | Punjabi_Muslim_India | 0.1417 |
North-West South Asian reference group, demonstrating strong ties into North-West South Asia.
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| Rank | Mixed 2-Population Model | Distance | Model Analysis |
|---|---|---|---|
| Best Fit | 50% Karnataka_Muslim + 50% Mumbai_Jew | 0.1281 |
Balances West Coast South Indian (Karnataka) with Western Indian (Mumbai/Konkan).
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| #2 | 60% Karnataka_Muslim + 40% Parsi_India_o | 0.1299 |
Mixes West Coast Indian with Western Parsi baseline coordinates.
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| #3 | 80% Cochin_Jew_B + 20% Mumbai_Jew | 0.1304 |
West Coast Indian baseline with minor Konkan/Mumbai shift.
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| #4 | 80% Cochin_Jew_B + 20% Karnataka_Muslim | 0.1308 |
Pure West Coast South Asian coastal blend.
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Adjust the interactive ratio slider to test how mixing Karnataka Muslim (West Coast) and Mumbai Jew (Western India) dynamically alters the estimated distance to the G25 coordinates.
Strict 2:00 PM Cutoff: Due to slow CYP1A2 C/C caffeine clearance (~6-8 hr half-life) and moderate ADORA2A sensitivity, limit daily caffeine to ≤ 200 mg and avoid coffee/tea past 2 PM to preserve restorative deep REM sleep.
Standard Dietary Folate: Homozygous wild-type MTHFR 677C (`G/G`) status guarantees 100% normal enzyme conversion. High-dose methylated 5-MTHF supplements are unneeded; natural dietary folate (spinach, legumes) is processed optimally.
90-Minute Focus Blocks: Balanced COMT Val/Met genotype provides an optimal prefrontal dopamine baseline. Capitalize on peak mental energy with structured 90-min deep work blocks followed by 10-min mental breaks.
Endurance & Oxidative Recovery: The ACTN3 577X (T/T) fast-twitch deficiency naturally shifts muscle metabolism toward aerobic efficiency. Prioritize high-volume resistance training, Zone-2 cardio, and steady recovery protocols.
| Trait / Biological Pathway | Gene & Genotype | Detailed Interpretation & Real-World Phenotype Impact |
|---|---|---|
| Dopamine & Stress Response |
COMT Val158Met rs4680: G / A |
Balanced "Flex-Metabolizer"
Carries one high-activity "Warrior" allele (
Val) and one low-activity "Worrier" allele (Met). This produces an optimal baseline dopamine degradation rate in the prefrontal cortex.
⚡ Real-World Impact: Maintains high cognitive focus and memory retention during complex tasks, while staying calm and resilient under high-pressure stress without experiencing quick mental burnout.
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| Caffeine Clearance Rate |
CYP1A2 163A>C rs762551: C / C |
Slow Caffeine Metabolizer
Hepatic CYP1A2 cytochrome P450 enzyme breaks down caffeine more slowly than average (extended caffeine half-life of ~6 to 8 hours).
☕ Real-World Impact: Coffee or tea provides a long-lasting boost in mental alertness from small doses. However, caffeine consumed past 2:00 PM remains active in the bloodstream at night and can disrupt deep REM sleep architectures.
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| Caffeine Sensitivity / Anxiety |
A2AR Adenosine Receptor rs5751876: T / C |
Moderate Caffeine Sensitivity
Carries one copy of the adenosine A2A receptor variant associated with heightened central nervous system sensitivity to caffeine.
⚡ Real-World Impact: Moderate coffee consumption enhances focus, but very high doses of caffeine (e.g., pre-workout supplements or multiple espresso shots) can occasionally trigger mild jitters or elevated heart rate.
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| Satiety & Appetite Control |
FTO Fat-Mass Gene rs9939609: T / T |
Protective Genotype (Low Risk)
Homozygous for the protective
T allele at the FTO locus, maintaining normal hypothalamic satiety signaling via leptin and ghrelin.
🥗 Real-World Impact: Presents normal, healthy appetite control and a lower baseline genetic predisposition to overeating, emotional snacking, or metabolic weight gain compared to
A-allele risk carriers.
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| Predicted Blood Group |
ABO Glycosyltransferase rs8176719: 0 / 0 (D/D) |
Predicted Type O Blood
Homozygous for the 261delG frameshift deletion in exon 6 of the ABO gene, which completely inactivates A and B glycosyltransferase enzymes.
🩸 Real-World Impact: Red blood cells present the un-modified H antigen (Type O phenotype). (Confirmed on Page 22 of the report; confirm via clinical blood test).
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| Bitter Taste Sensitivity |
TAS2R38 Taste Receptor rs713598: C / C |
Moderate Bitter Taster
Carries the
AVI / AVV taste receptor haplotype, providing balanced sensitivity to glucosinolates and PTC bitter compounds.
🥦 Real-World Impact: Tastes mild bitter notes in dark chocolate, espresso, and cruciferous vegetables (broccoli, kale, Brussels sprouts) without finding them overwhelmingly repulsive or tasteless.
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| Sleep Schedule & Chronotype |
CLOCK Gene rs1801260: A / G |
Flexible Circadian Rhythm
Heterozygous for the 3111T>C clock gene variant that regulates suprachiasmatic nucleus circadian timing.
🌙 Real-World Impact: Highly adaptable circadian rhythm. Easily adjusts to to early morning meetings or late evening work sessions without experiencing severe daytime grogginess.
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| Endogenous Pain Threshold |
OPRM1 Opioid Receptor rs1799971: A / G |
Slightly Higher Pain Threshold
Carries one copy of the
118G variant in the mu-opioid receptor gene (OPRM1).
🩹 Real-World Impact: Alters endomorphin receptor binding, resulting in a slightly higher baseline tolerance to physical pain or muscle soreness following heavy exertion.
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| Lactose Digestion |
MCM6 / LCT Gene rs4988235: A / A |
Lactase Persistence (Tolerant)
Homozygous for the Eurasian
-13910*T (A) persistence enhancer mutation upstream of the LCT lactase gene.
🥛 Real-World Impact: The body continues to produce the lactase enzyme throughout adulthood, allowing comfortable digestion of fresh milk, yogurt, and dairy products without bloating.
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| Muscle Performance Profile |
ACTN3 Alpha-Actinin-3 rs1815739: T / T |
Endurance / Metabolic Muscle Profile
Homozygous for the
577X null allele (T/T), leading to alpha-actinin-3 deficiency in fast-twitch skeletal muscle fibers.
🏋️ Real-World Impact: Muscle metabolism naturally favors slow-twitch oxidative efficiency, promoting high endurance capacity, resistance to muscle fatigue, and efficient aerobic recovery.
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| Alcohol Metabolism (Flush) |
ALDH2 Dehydrogenase rs671: G / G |
Normal Alcohol Metabolism
Homozygous for the wild-type ALDH2*1 allele, producing fully functional aldehyde dehydrogenase enzymes.
🍷 Real-World Impact: Acetaldehyde is efficiently converted to acetate in the liver, preventing facial flushing, nausea, or rapid heart rate associated with the East Asian flush response.
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| COVID-19 Severity Risk |
LZTFL1 Introgressed Locus rs35044562: C / T |
1 Neanderthal Risk Copy
Heterozygous for the Neanderthal-introgressed chr3p21.31 risk haplotype locus.
🛡️ Real-World Impact: Evolutionary observation from published GWAS scans (Zeberg & Pääbo 2020). Associated with slightly elevated inflammatory response during severe respiratory infections.
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| Folate Metabolism Pathway |
MTHFR Reductase rs1801133: G / G |
Normal Enzyme Function
Homozygous wild-type (
C677C equivalent) for 5,10-methylenetetrahydrofolate reductase.
🌿 Real-World Impact: Optimal enzymatic conversion of dietary folate into active methylfolate for cell division, DNA repair, and homocysteine regulation.
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