Genomic, Ancestry & Admixture Dashboard • GRCh37 VCF Analysis
| Ancestral Stream | Share | Historical Period, Archaeology & Evolutionary Context |
|---|---|---|
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Indus Valley Civilization South Asian Bronze Age |
A composite IVC-related proxy carrying both Iranian-related farmer ancestry and indigenous South Asian ancestry.
Includes both Iranian-related farmer and AASI-related ancestry.
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AASI-related Indigenous South Asian |
Additional AASI-related ancestry outside the ancestry already embedded in the IVC proxy.
Interpretation: A statistical deep-ancestry proxy, not a sampled unmixed AASI genome.
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Central Steppe Bronze Age Herders |
Steppe-related Bronze Age ancestry represented by Central Steppe reference populations.
Consistent with the approximately 17–20% Steppe-related signal across the best models.
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| BMAC Central Asia |
7.2% | Bactria–Margiana Archaeological Complex-related ancestry, representing southern Central Asian Bronze Age affinity. |
| Bronze Age Caucasian Caucasus |
4.8% | A smaller Caucasus-related signal in the tailored Bronze Age model. |
| Sub-Saharan African Trace |
0.6% | Trace-sized output; too small and model-sensitive to interpret as a specific recent genealogical ancestor. |
| Rank | Population Reference | Distance | Detailed Regional Context & Significance |
|---|---|---|---|
| #1 | Meena Rajasthan | 2.345 |
Closest modern reference; northern/western South Asian affinity.
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| #2 | Punjabi Lahore | 2.479 |
Strong northwestern South Asian affinity.
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| #3 | Brahmin Andhra Pradesh | 2.516 |
A nearby South Asian reference reflecting a similar broad ancestry balance.
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| #4 | Gujarati B | 2.608 |
Supports western Indian affinity within the broader South Asian continuum.
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| #5 | Brahmin Tamil Nadu | 2.645 |
Close southern Indian reference with a similar broad ancestry balance.
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| #6 | Gujarati C | 2.827 | Western Indian reference. |
| #7 | Kshatriya Uttar Pradesh | 2.937 | North-central Indian reference. |
| #8 | Gujarati | 3.759 | Broad Gujarati reference. |
| #9 | Brahmin Uttar Pradesh | 3.809 | North-central Indian reference. |
| #10 | Cochin Jew | 4.140 | Southwestern coastal Indian reference. |
| #11 | Gujar Rajasthan | 4.232 | Rajasthani reference. |
| #12 | Meghawal Rajasthan | 4.899 | Rajasthani reference. |
| #13 | Gujarati D | 4.918 | Western Indian reference. |
| #14 | Kurmi Uttar Pradesh | 5.035 | North-central Indian reference. |
| #15 | Lambadi Andhra Pradesh | 5.146 | South-central Indian reference. |
| Rank | Ancient Reference | Distance | Interpretation |
|---|---|---|---|
| #1 | Medieval Indian Roopkund | 4.116 |
Closest ancient reference.
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| #2 | Gandhara Indo-Greek | 4.674 |
Supports affinity to ancient populations from the northwestern subcontinent.
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| #3 | Indus Valley Civilization | 5.224 |
Directly reflects the major IVC-related ancestry signal.
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| #4 | Gandhara Mauryan | 5.846 |
A second close Gandhara-period comparison.
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| #5 | Gandhara Saka-Parthian | 7.026 | Northwestern South Asian Iron Age affinity. |
| #6 | Medieval Swat Barikot | 7.151 | Swat Valley historical-period affinity. |
| #7 | Gandhara Grave Culture | 8.082 | Bronze/Iron Age northwestern affinity. |
| #8 | Indian Mauryan | 8.114 | Ancient Indian reference. |
| #9 | Medieval Swat Udegram | 12.365 | Later Swat Valley reference. |
| #10 | Post-Medieval Swat Singoor | 12.859 | Post-medieval northwestern reference. |
Likely slower caffeine handling. A sensible experiment is a 6–8 hour pre-sleep cutoff for two weeks, then judge by sleep quality. Smoking, medication and habitual intake can change the effect.
No common MTHFR C677T reduced-function allele detected. Ordinary folate-rich food is a reasonable baseline; this result alone gives no special reason to prefer methylfolate supplements.
COMT Val/Met is an intermediate-activity genotype. It is compatible with a middle-of-the-range dopamine breakdown tendency, but actual focus and stress response should be judged from experience, not this SNP alone.
ACTN3 577X/X is the clearest muscle finding. It removes functional alpha-actinin-3 and modestly favors endurance-oriented physiology. Endurance and mixed training may feel natural, while power can still be developed normally with training.
| Trait / Biological Pathway | Gene & Genotype | Interpretation |
|---|---|---|
| Dopamine & Stress Response |
COMT Val158Met rs4680: G / A |
Val/Met genotype
Intermediate COMT activity on average; individual cognitive and stress effects are usually small.
Limit: This single marker cannot predict focus, memory, resilience or response to stress for an individual.
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| Caffeine Clearance Rate |
CYP1A2 163A>C rs762551: C / C |
Slow Caffeine Metabolizer
Associated with slower caffeine clearance; sleep response remains the best personal guide.
Limit: It does not establish a personal 6–8 hour half-life or a universal 2 PM cutoff. Observed sleep response is more actionable.
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| Caffeine Sensitivity / Anxiety |
A2AR Adenosine Receptor rs5751876: T / C |
Moderate Caffeine Sensitivity
Associated with moderate caffeine sensitivity and a greater chance of jitters at high doses.
Limit: Jitters and alertness depend strongly on dose, tolerance, sleep and other factors; this SNP is not determinative.
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| Satiety & Appetite Control |
FTO Fat-Mass Gene rs9939609: T / T |
Protective Genotype (Low Risk)
Two non-risk alleles at this common FTO weight-association marker.
Limit: This is one small-effect association and cannot predict appetite control, eating behavior or body weight.
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| Predicted Blood Group |
ABO Glycosyltransferase rs8176719: 0 / 0 (D/D) |
Predicted Type O Blood
Homozygous for the 261delG frameshift deletion in exon 6 of the ABO gene, which completely inactivates A and B glycosyltransferase enzymes.
Limit: The deletion call has low genotype quality and ABO type also depends on other alleles. Treat Type O as tentative and confirm with a blood-typing test.
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| Bitter Taste Sensitivity |
TAS2R38 Taste Receptor rs713598: C / C |
Moderate Bitter Taster
Consistent with bitter-taste sensitivity, although the full TAS2R38 haplotype is not phased here.
Limit: TAS2R38 taste phenotype requires a correctly phased multi-SNP haplotype and does not reliably predict preferences from this marker alone.
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| Sleep Schedule & Chronotype |
CLOCK Gene rs1801260: A / G |
Flexible Circadian Rhythm
A common CLOCK variant with small and inconsistent chronotype associations.
Limit: One CLOCK association cannot establish chronotype or adaptability; sleep history and behavior are much stronger evidence.
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| Endogenous Pain Threshold |
OPRM1 Opioid Receptor rs1799971: A / G |
Association is inconsistent
Carries one copy of the
118G variant in the mu-opioid receptor gene (OPRM1).
Limit: Published effects vary by population and endpoint. Do not infer an individual pain threshold or medication response from this SNP.
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| Lactose Digestion |
MCM6 / LCT Gene rs4988235: A / A |
Lactase Persistence (Tolerant)
Homozygous for the Eurasian
-13910*T (A) persistence enhancer mutation upstream of the LCT lactase gene.
Interpretation: This genotype supports European-associated lactase persistence, but symptoms still depend on dose, gut health and ancestry-specific variants.
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| Muscle Performance Profile |
ACTN3 Alpha-Actinin-3 rs1815739: T / T |
ACTN3 deficiency; modest endurance association
Homozygous for the
577X null allele (T/T), leading to alpha-actinin-3 deficiency in fast-twitch skeletal muscle fibers.
Limit: Population studies show a modest shift toward endurance phenotypes, not guaranteed endurance, fatigue resistance or recovery. Training history dominates performance.
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| Alcohol Metabolism (Flush) |
ALDH2 Dehydrogenase rs671: G / G |
No ALDH2*2 allele at rs671
Homozygous for the wild-type ALDH2*1 allele, producing fully functional aldehyde dehydrogenase enzymes.
Limit: This lowers the likelihood of classic ALDH2*2 flushing but does not make alcohol safe or rule out symptoms from other causes.
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| Folate Metabolism Pathway |
MTHFR Reductase rs1801133: G / G |
Common non-677T genotype
The VCF call is consistent with no copies of the common C677T reduced-function allele.
Limit: This does not guarantee optimal folate metabolism or determine supplement requirements; diet, other variants and laboratory values matter.
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